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Oxidation of Atg3 and Atg7 mediates inhibition of autophagy

Macroautophagy (autophagy) is a crucial cellular stress response for degrading defective macromolecules and organelles, as well as providing bioenergetic intermediates during hypoxia and nutrient deprivation. Here we report a thiol-dependent process that may account for impaired autophagy during agi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Frudd, Karen, Burgoyne, Thomas, Burgoyne, Joseph Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5758830/
https://ncbi.nlm.nih.gov/pubmed/29311554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02352-z
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