Effect of Noncanonical Amino Acids on Protein–Carbohydrate Interactions: Structure, Dynamics, and Carbohydrate Affinity of a Lectin Engineered with Fluorinated Tryptophan Analogs

[Image: see text] Protein–carbohydrate interactions play crucial roles in biology. Understanding and modifying these interactions is of major interest for fighting many diseases. We took a synthetic biology approach and incorporated noncanonical amino acids into a bacterial lectin to modulate its in...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Tobola, Felix, Lelimousin, Mickael, Varrot, Annabelle, Gillon, Emilie, Darnhofer, Barbara, Blixt, Ola, Birner-Gruenberger, Ruth, Imberty, Anne, Wiltschi, Birgit
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2018
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102642/
https://ncbi.nlm.nih.gov/pubmed/29812892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00377
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