Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells

Type I interferon (IFN) is a key driver of immunity to infections and cancer. Plasmacytoid dendritic cells (pDCs) are uniquely equipped to produce large quantities of type I IFN but the mechanisms that control this process are poorly understood. Here we report on a droplet-based microfluidic platfor...

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Pubblicato in:Nat Commun
Autori principali: Wimmers, Florian, Subedi, Nikita, van Buuringen, Nicole, Heister, Daan, Vivié, Judith, Beeren-Reinieren, Inge, Woestenenk, Rob, Dolstra, Harry, Piruska, Aigars, Jacobs, Joannes F. M., van Oudenaarden, Alexander, Figdor, Carl G., Huck, Wilhelm T. S., de Vries, I. Jolanda M., Tel, Jurjen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102223/
https://ncbi.nlm.nih.gov/pubmed/30127440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05784-3
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