Molecular mechanism of HIV-1 resistance to sifuvirtide, a clinical trial–approved membrane fusion inhibitor

Host cell infection with HIV-1 requires fusion of viral and cell membranes. Sifuvirtide (SFT) is a peptide-based HIV-1 fusion inhibitor approved for phase III clinical trials in China. Here, we focused on characterizing HIV-1 variants highly resistant to SFT to gain insight into the molecular resist...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yu, Danwei, Ding, Xiaohui, Liu, Zixuan, Wu, Xiyuan, Zhu, Yuanmei, Wei, Huanmian, Chong, Huihui, Cui, Sheng, He, Yuxian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102148/
https://ncbi.nlm.nih.gov/pubmed/29929981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003538
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