Exceptional potency and structural basis of a T1249-derived lipopeptide fusion inhibitor against HIV-1, HIV-2, and simian immunodeficiency virus

Enfuvirtide (T20) is the only viral fusion inhibitor approved for clinical use, but it has relatively weak anti-HIV activity and easily induces drug resistance. In succession to T20, T1249 has been designed as a 39-mer peptide composed of amino acid sequences derived from HIV-1, HIV-2, and simian im...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Zhu, Yuanmei, Zhang, Xiujuan, Ding, Xiaohui, Chong, Huihui, Cui, Sheng, He, Jinsheng, Wang, Xinquan, He, Yuxian
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892594/
https://ncbi.nlm.nih.gov/pubmed/29425101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001729
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