Disulfide-crosslink scanning reveals prion–induced conformational changes and prion strain–specific structures of the pathological prion protein PrP(Sc)

Prions are composed solely of the pathological isoform (PrP(Sc)) of the normal cellular prion protein (PrP(C)). Identification of different PrP(Sc) structures is crucially important for understanding prion biology because the pathogenic properties of prions are hypothesized to be encoded in the stru...

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Vydáno v:J Biol Chem
Hlavní autoři: Taguchi, Yuzuru, Lu, Li, Marrero-Winkens, Cristobal, Otaki, Hiroki, Nishida, Noriyuki, Schatzl, Hermann M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102138/
https://ncbi.nlm.nih.gov/pubmed/29934306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001633
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