Disulfide-crosslink scanning reveals prion–induced conformational changes and prion strain–specific structures of the pathological prion protein PrP(Sc)

Prions are composed solely of the pathological isoform (PrP(Sc)) of the normal cellular prion protein (PrP(C)). Identification of different PrP(Sc) structures is crucially important for understanding prion biology because the pathogenic properties of prions are hypothesized to be encoded in the stru...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Taguchi, Yuzuru, Lu, Li, Marrero-Winkens, Cristobal, Otaki, Hiroki, Nishida, Noriyuki, Schatzl, Hermann M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102138/
https://ncbi.nlm.nih.gov/pubmed/29934306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001633
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