A carregar...
Improved sgRNA design in bacteria via genome-wide activity profiling
CRISPR/Cas9 is a promising tool in prokaryotic genome engineering, but its success is limited by the widely varying on-target activity of single guide RNAs (sgRNAs). Based on the association of CRISPR/Cas9-induced DNA cleavage with cellular lethality, we systematically profiled sgRNA activity by co-...
Na minha lista:
| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6101607/ https://ncbi.nlm.nih.gov/pubmed/29982721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky572 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|