Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades

Heat shock protein 70 (Hsp70) is a molecular chaperone that binds to “client” proteins and protects them from protein degradation. Hsp70 is essential for the survival of many cancer cells, but it is not yet clear which of its clients are involved. Using structurally distinct chemical inhibitors, we...

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Veröffentlicht in:Mol Cancer Res
Hauptverfasser: Srinivasan, Sharan R., Cesa, Laura C., Li, Xiaokai, Julien, Olivier, Zhuang, Min, Shao, Hao, Chung, Jooho, Maillard, Ivan, Wells, James A., Duckett, Colin, Gestwicki, Jason E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6101036/
https://ncbi.nlm.nih.gov/pubmed/28970360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0408
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