Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades

Heat shock protein 70 (Hsp70) is a molecular chaperone that binds to “client” proteins and protects them from protein degradation. Hsp70 is essential for the survival of many cancer cells, but it is not yet clear which of its clients are involved. Using structurally distinct chemical inhibitors, we...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Srinivasan, Sharan R., Cesa, Laura C., Li, Xiaokai, Julien, Olivier, Zhuang, Min, Shao, Hao, Chung, Jooho, Maillard, Ivan, Wells, James A., Duckett, Colin, Gestwicki, Jason E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6101036/
https://ncbi.nlm.nih.gov/pubmed/28970360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0408
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