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Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis

Since cells in solid tumors divide less rapidly than cells in the bone marrow or cells of the immune system, mitotic inhibitors often cause severe side effects when used for treatment of diseases like prostate cancer and breast cancer. One approach to overcome this problem involves attempts at devel...

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Bibliographic Details
Published in:Molecules
Main Authors: Zimmermann, Tomas, Christensen, Søren Brøgger, Franzyk, Henrik
Format: Artigo
Language:Inglês
Published: MDPI 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6100299/
https://ncbi.nlm.nih.gov/pubmed/29914143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23061463
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