Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity

Despite the controversial outcomes of clinical trials executed so far, the prevention of β-amyloid (Aβ) deposition and neurotoxicity by small molecule inhibitors of Aβ aggregation remains a target intensively pursued in the search of effective drugs for treating Alzheimer’s disease (AD) and related...

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Опубликовано в: :Molecules
Главные авторы: Purgatorio, Rosa, de Candia, Modesto, De Palma, Annalisa, De Santis, Francesco, Pisani, Leonardo, Campagna, Francesco, Cellamare, Saverio, Altomare, Cosimo Damiano, Catto, Marco
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6100259/
https://ncbi.nlm.nih.gov/pubmed/29949947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23071544
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