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Structure-Activity Relationships Based on 3D-QSAR CoMFA/CoMSIA and Design of Aryloxypropanol-Amine Agonists with Selectivity for the Human β3-Adrenergic Receptor and Anti-Obesity and Anti-Diabetic Profiles

The wide tissue distribution of the adrenergic β3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there is only one drug on the market, mirabegron, approved for the treatment of OAB...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Molecules
Autori principali: Lorca, Marcos, Morales-Verdejo, Cesar, Vásquez-Velásquez, David, Andrades-Lagos, Juan, Campanini-Salinas, Javier, Soto-Delgado, Jorge, Recabarren-Gajardo, Gonzalo, Mella, Jaime
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099677/
https://ncbi.nlm.nih.gov/pubmed/29772697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23051191
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