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3D-QSAR Studies of Latrunculin-Based Actin Polymerization Inhibitors Using CoMFA and CoMSIA Approaches
The marine-derived macrolide latrunculins A and B, from the Red Sea sponge Negombata magnifica, are known to reversibly bind actin monomers, forming 1:1 complex with G-actin, disrupting its polymerization. Latrunculins have remarkable physiological properties and widely used as biochemical markers....
Tallennettuna:
| Päätekijät: | , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2918725/ https://ncbi.nlm.nih.gov/pubmed/20684858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2010.05.012 |
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