Ligand‐Induced Conformational Changes in HSP90 Monitored Time Resolved and Label Free—Towards a Conformational Activity Screening for Drug Discovery

Investigation of protein–ligand interactions is crucial during early drug‐discovery processes. ATR‐FTIR spectroscopy can detect label‐free protein–ligand interactions with high spatiotemporal resolution. Here we immobilized, as an example, the heat shock protein HSP90 on an ATR crystal. This protein...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Güldenhaupt, Jörn, Amaral, Marta, Kötting, Carsten, Schartner, Jonas, Musil, Djordje, Frech, Matthias, Gerwert, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099472/
https://ncbi.nlm.nih.gov/pubmed/29772085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201802603
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