Ligand‐Induced Conformational Changes in HSP90 Monitored Time Resolved and Label Free—Towards a Conformational Activity Screening for Drug Discovery

Investigation of protein–ligand interactions is crucial during early drug‐discovery processes. ATR‐FTIR spectroscopy can detect label‐free protein–ligand interactions with high spatiotemporal resolution. Here we immobilized, as an example, the heat shock protein HSP90 on an ATR crystal. This protein...

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Detaylı Bibliyografya
Yayımlandı:Angew Chem Int Ed Engl
Asıl Yazarlar: Güldenhaupt, Jörn, Amaral, Marta, Kötting, Carsten, Schartner, Jonas, Musil, Djordje, Frech, Matthias, Gerwert, Klaus
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099472/
https://ncbi.nlm.nih.gov/pubmed/29772085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201802603
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