Exposure‐safety and efficacy response relationships and population pharmacokinetics of eslicarbazepine acetate

OBJECTIVES: Eslicarbazepine acetate (ESL) is a once‐daily (QD) oral antiepileptic drug (AED) for focal‐onset seizures (FOS). Pharmacokinetic (PK) and pharmacodynamic (PD) models were developed to assess dose selection, identify significant AED drug interactions, and quantitate relationships between...

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Publicado en:Acta Neurol Scand
Autores principales: Gidal, B. E., Jacobson, M. P., Ben‐Menachem, E., Carreño, M., Blum, D., Soares‐da‐Silva, P., Falcão, A., Rocha, F., Moreira, J., Grinnell, T., Ludwig, E., Fiedler‐Kelly, J., Passarell, J., Sunkaraneni, S.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099471/
https://ncbi.nlm.nih.gov/pubmed/29732549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ane.12950
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