Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice

Liver sinusoidal endothelial cells (LSECs) critically regulate liver homeostasis and diseases through angiocrine factors. Notch is critical in endothelial cells (ECs). In the current study, Notch signaling was activated by inducible EC‐specific expression of the Notch intracellular domain (NIC). We...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Hepatology
Main Authors: Duan, Juan‐Li, Ruan, Bai, Yan, Xian‐Chun, Liang, Liang, Song, Ping, Yang, Zi‐Yan, Liu, Yuan, Dou, Ke‐Feng, Han, Hua, Wang, Lin
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099357/
https://ncbi.nlm.nih.gov/pubmed/29420858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29834
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