Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice

Liver sinusoidal endothelial cells (LSECs) critically regulate liver homeostasis and diseases through angiocrine factors. Notch is critical in endothelial cells (ECs). In the current study, Notch signaling was activated by inducible EC‐specific expression of the Notch intracellular domain (NIC). We...

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Dettagli Bibliografici
Pubblicato in:Hepatology
Autori principali: Duan, Juan‐Li, Ruan, Bai, Yan, Xian‐Chun, Liang, Liang, Song, Ping, Yang, Zi‐Yan, Liu, Yuan, Dou, Ke‐Feng, Han, Hua, Wang, Lin
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099357/
https://ncbi.nlm.nih.gov/pubmed/29420858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29834
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