Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice

Liver sinusoidal endothelial cells (LSECs) critically regulate liver homeostasis and diseases through angiocrine factors. Notch is critical in endothelial cells (ECs). In the current study, Notch signaling was activated by inducible EC‐specific expression of the Notch intracellular domain (NIC). We...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Duan, Juan‐Li, Ruan, Bai, Yan, Xian‐Chun, Liang, Liang, Song, Ping, Yang, Zi‐Yan, Liu, Yuan, Dou, Ke‐Feng, Han, Hua, Wang, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099357/
https://ncbi.nlm.nih.gov/pubmed/29420858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29834
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