Late‐Stage Isotopic Carbon Labeling of Pharmaceutically Relevant Cyclic Ureas Directly from CO(2)

A robust, click‐chemistry‐inspired procedure for radiolabeling of cyclic ureas was developed. This protocol, suitable for all carbon isotopes ((11)C, (13)C, (14)C), is based on the direct functionalization of carbon dioxide: the universal building block for carbon radiolabeling. The strategy is oper...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Del Vecchio, Antonio, Caillé, Fabien, Chevalier, Arnaud, Loreau, Olivier, Horkka, Kaisa, Halldin, Christer, Schou, Magnus, Camus, Nathalie, Kessler, Pascal, Kuhnast, Bertrand, Taran, Frédéric, Audisio, Davide
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099343/
https://ncbi.nlm.nih.gov/pubmed/29862657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201804838
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