Late‐Stage Isotopic Carbon Labeling of Pharmaceutically Relevant Cyclic Ureas Directly from CO(2)

A robust, click‐chemistry‐inspired procedure for radiolabeling of cyclic ureas was developed. This protocol, suitable for all carbon isotopes ((11)C, (13)C, (14)C), is based on the direct functionalization of carbon dioxide: the universal building block for carbon radiolabeling. The strategy is oper...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Del Vecchio, Antonio, Caillé, Fabien, Chevalier, Arnaud, Loreau, Olivier, Horkka, Kaisa, Halldin, Christer, Schou, Magnus, Camus, Nathalie, Kessler, Pascal, Kuhnast, Bertrand, Taran, Frédéric, Audisio, Davide
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099343/
https://ncbi.nlm.nih.gov/pubmed/29862657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201804838
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