Genome Wide Distribution of Linker Histone H1.0 is Independent of MeCP2

Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed ChIP-Seq of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 occupied similar genomic regions and the Flag-H1.0 bindin...

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Vydáno v:Nat Neurosci
Hlavní autoři: Ito-Ishida, Aya, Yamalanchili, Hari K., Shao, Yingyao, Baker, Steven A., Heckman, Laura D., Lavery, Laura A., Kim, Ji-yoen, Lombardi, Laura M., Sun, Yaling, Liu, Zhandong, Zoghbi, Huda Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099063/
https://ncbi.nlm.nih.gov/pubmed/29802390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0155-8
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