ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation

Lipid peroxidation (LPO) products are relatively stable and abundant metabolites, which accumulate in tissues of mammals with aging, being able to modify all cellular nucleophiles, creating protein and DNA adducts including crosslinks. Here, we used cells and mice deficient in the ERCC1-XPF endonucl...

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Pubblicato in:Free Radic Biol Med
Autori principali: Czerwińska, Jolanta, Nowak, Małgorzata, Wojtczak, Patrycja, Dziuban-Lech, Dorota, Cieśla, Jarosław M., Kołata, Daria, Gajewska, Beata, Barańczyk-Kuźma, Anna, Robinson, Andria R., Shane, Hillary L., Gregg, Siobhán Q., Rigatti, Lora H., Yousefzadeh, Matthew J., Gurkar, Aditi U., McGowan, Sara J., Kosicki, Konrad, Bednarek, Małgorzata, Zarakowska, Ewelina, Gackowski, Daniel, Oliński, Ryszard, Speina, Elżbieta, Niedernhofer, Laura J., Tudek, Barbara
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6098728/
https://ncbi.nlm.nih.gov/pubmed/29860127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2018.05.088
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