Production, quality control, stability, and potency of cGMP-produced Plasmodium falciparum RH5.1 protein vaccine expressed in Drosophila S2 cells

Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is a leading asexual blood-stage vaccine candidate for malaria. In preparation for clinical trials, a full-length PfRH5 protein vaccine called “RH5.1” was produced as a soluble product under cGMP using the ExpreS(2) platform (based...

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Detalhes bibliográficos
Publicado no:NPJ Vaccines
Main Authors: Jin, Jing, Tarrant, Richard D., Bolam, Emma J., Angell-Manning, Philip, Soegaard, Max, Pattinson, David J., Dulal, Pawan, Silk, Sarah E., Marshall, Jennifer M., Dabbs, Rebecca A., Nugent, Fay L., Barrett, Jordan R., Hjerrild, Kathryn A., Poulsen, Lars, Jørgensen, Thomas, Brenner, Tanja, Baleanu, Ioana N., Parracho, Helena M., Tahiri-Alaoui, Abdessamad, Whale, Gary, Moyle, Sarah, Payne, Ruth O., Minassian, Angela M., Higgins, Matthew K., Detmers, Frank J., Lawrie, Alison M., Douglas, Alexander D., Smith, Robert, de Jongh, Willem A., Berrie, Eleanor, Ashfield, Rebecca, Draper, Simon J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6098134/
https://ncbi.nlm.nih.gov/pubmed/30131879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-018-0071-7
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