Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal ‘C-tag’

Development of bespoke biomanufacturing processes remains a critical bottleneck for translational studies, in particular when modest quantities of a novel product are required for proof-of-concept Phase I/II clinical trials. In these instances the ability to develop a biomanufacturing process quickl...

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Udgivet i:Int J Parasitol
Main Authors: Jin, Jing, Hjerrild, Kathryn A., Silk, Sarah E., Brown, Rebecca E., Labbé, Geneviève M., Marshall, Jennifer M., Wright, Katherine E., Bezemer, Sandra, Clemmensen, Stine B., Biswas, Sumi, Li, Yuanyuan, El-Turabi, Aadil, Douglas, Alexander D., Hermans, Pim, Detmers, Frank J., de Jongh, Willem A., Higgins, Matthew K., Ashfield, Rebecca, Draper, Simon J.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482323/
https://ncbi.nlm.nih.gov/pubmed/28153778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpara.2016.12.001
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