Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter

p62/SQSTM1 is the key autophagy adapter protein and the hub of multi-cellular signaling. It was recently reported that autophagy and N-end rule pathways are linked via p62. However, the exact recognition mode of degrading substrates and regulation of p62 in the autophagic pathway remain unknown. Her...

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Publicado no:Nat Commun
Main Authors: Kwon, Do Hoon, Park, Ok Hyun, Kim, Leehyeon, Jung, Yang Ouk, Park, Yeonkyoung, Jeong, Hyeongseop, Hyun, Jaekyung, Kim, Yoon Ki, Song, Hyun Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6098011/
https://ncbi.nlm.nih.gov/pubmed/30120248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05825-x
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