FANCA promotes DNA double strand break repair by catalyzing single-strand annealing and strand exchange

FANCA is a component of the Fanconi anemia (FA) core complex that activates DNA interstrand crosslink repair by monoubiquitination of FANCD2. Here, we report that purified FANCA protein catalyzes bidirectional single-strand annealing (SA) and strand exchange (SE) at a level comparable to RAD52, whil...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Benitez, Anaid, Liu, Wenjun, Palovcak, Anna, Wang, Guanying, Moon, Jaewon, An, Kevin, Kim, Anna, Zheng, Kevin, Zhang, Yu, Bai, Feng, Mazin, Alexander V., Pei, Xin-Hai, Yuan, Fenghua, Zhang, Yanbin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097932/
https://ncbi.nlm.nih.gov/pubmed/30057198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.030
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