Lithium Enolates in the Enantioselective Construction of Tetrasubstituted Carbon Centers with Chiral Lithium Amides as Non-Covalent Stereodirecting Auxiliaries

Lithium enolates derived from carboxylic acids are ubiquitous intermediates in organic synthesis. Asymmetric transformations with these intermediates, a central goal of organic synthesis, are typically carried out with covalently attached chiral auxiliaries. An alternative approach is to utilize rea...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Lu, Ping, Jackson, Jeffrey, Yu, Kai, Nguyen, Bi, Alvarado, Joseph, Stivala, Craig E., Ma, Yun, Mack, Kyle A., Hayton, Trevor, Collum, David B., Zakarian, Armen
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097510/
https://ncbi.nlm.nih.gov/pubmed/27997174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11673
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