Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone

BACKGROUND: The major complaint of knee osteoarthritis (OA) is persistent pain. Unlike acute inflammatory pain, persistent pain is usually difficult to manage since its pathology is not fully understood. To elucidate the underlying mechanisms of persistent pain, we established 2 different inflammati...

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Bibliografiske detaljer
Udgivet i:BMC Musculoskelet Disord
Main Authors: Hoshino, Takashi, Tsuji, Kunikazu, Onuma, Hiroaki, Udo, Mio, Ueki, Hiroko, Akiyama, Masako, Abula, Kahaer, Katagiri, Hiroki, Miyatake, Kazumasa, Watanabe, Toshihumi, Sekiya, Ichiro, Koga, Hideyuki, Muneta, Takeshi
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097215/
https://ncbi.nlm.nih.gov/pubmed/30115046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-018-2221-5
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