Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone

BACKGROUND: The major complaint of knee osteoarthritis (OA) is persistent pain. Unlike acute inflammatory pain, persistent pain is usually difficult to manage since its pathology is not fully understood. To elucidate the underlying mechanisms of persistent pain, we established 2 different inflammati...

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Vydáno v:BMC Musculoskelet Disord
Hlavní autoři: Hoshino, Takashi, Tsuji, Kunikazu, Onuma, Hiroaki, Udo, Mio, Ueki, Hiroko, Akiyama, Masako, Abula, Kahaer, Katagiri, Hiroki, Miyatake, Kazumasa, Watanabe, Toshihumi, Sekiya, Ichiro, Koga, Hideyuki, Muneta, Takeshi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097215/
https://ncbi.nlm.nih.gov/pubmed/30115046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12891-018-2221-5
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