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Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers

BACKGROUND: The Tn neoantigen (GalNAcα1-O-Ser/Thr) is an O-glycan expressed in various types of human cancers. Studies in several Tn-expressing cancer cell lines and pancreatic tumors have identified loss of Cosmc expression caused by either mutations or promoter hypermethylation. In this study, we...

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Publicat a:BMC Cancer
Autors principals: Sun, Xiaodong, Ju, Tongzhong, Cummings, Richard D.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097208/
https://ncbi.nlm.nih.gov/pubmed/30115016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4708-8
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