Epigenetic Silencing of the Chaperone Cosmc in Human Leukocytes Expressing Tn Antigen

Cosmc is the specific molecular chaperone in the endoplasmic reticulum for T-synthase, a Golgi β3-galactosyltransferase that generates the core 1 O-glycan, Galβ1–3GalNAcα-Ser/Thr, in glycoproteins. Dysfunctional Cosmc results in the formation of inactive T-synthase and consequent expression of the T...

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Detalhes bibliográficos
Main Authors: Mi, Rongjuan, Song, Lina, Wang, Yingchun, Ding, Xiaokun, Zeng, Junwei, Lehoux, Sylvain, Aryal, Rajindra P., Wang, Jianmei, Crew, Vanja K., van Die, Irma, Chapman, Arlene B., Cummings, Richard D., Ju, Tongzhong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510848/
https://ncbi.nlm.nih.gov/pubmed/23035125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.371989
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