Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach

PURPOSE: Changes in drug absorption and first-pass metabolism have been reported throughout the pediatric age range. Our aim is to characterize both intestinal and hepatic CYP3A-mediated metabolism of midazolam in children in order to predict first-pass and systemic metabolism of CYP3A substrates. M...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Brussee, Janneke M., Yu, Huixin, Krekels, Elke H. J., Palić, Semra, Brill, Margreke J. E., Barrett, Jeffrey S., Rostami-Hodjegan, Amin, de Wildt, Saskia N., Knibbe, Catherijne A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096899/
https://ncbi.nlm.nih.gov/pubmed/30062590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-018-2458-6
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