Coated and Hollow Microneedle-Mediated Intradermal Immunization in Mice with Diphtheria Toxoid Loaded Mesoporous Silica Nanoparticles

PURPOSE: To examine the immunogenicity of diphtheria toxoid (DT) loaded mesoporous silica nanoparticles (MSNs) after coated and hollow microneedle-mediated intradermal immunization in mice. METHODS: DT was loaded into MSNs and the nanoparticle surface was coated with a lipid bilayer (LB-MSN-DT). To...

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Udgivet i:Pharm Res
Main Authors: Du, Guangsheng, Woythe, Laura, van der Maaden, Koen, Leone, Mara, Romeijn, Stefan, Kros, Alexander, Kersten, Gideon, Jiskoot, Wim, Bouwstra, Joke A.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096895/
https://ncbi.nlm.nih.gov/pubmed/30105542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-018-2476-4
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