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Microneedle-Based Transcutaneous Immunisation in Mice with N-Trimethyl Chitosan Adjuvanted Diphtheria Toxoid Formulations
PURPOSE: The purpose of this study was to gain insight into the delivery and immunogenicity of N-trimethyl chitosan (TMC) adjuvanted diphtheria toxoid (DT) formulations applied transcutaneously with microneedles. METHODS: Mice were vaccinated with DT-loaded TMC nanoparticles, a solution of TMC and D...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer US
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2920068/ https://ncbi.nlm.nih.gov/pubmed/20559701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-010-0182-y |
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