Synthesis and evaluation of 6-heteroarylamino-2,4,5-trimethylpyridin-3-ols as inhibitors of TNF-α-induced cell adhesion and inflammatory bowel disease

Inflammatory bowel disease (IBD) is an inflammatory disease of the gastrointestinal tract with complex pathogenesis. Here, we synthesized 6-heteroarylamino analogues to inhibit TNF-α-induced adhesion of monocytes to colon epithelial cells which are implicated in the initial inflammation process of I...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Park, Sang Won, Banskota, Suhrid, Gurung, Pallavi, Jin, You Jin, Kang, Han-eol, Chaudhary, Chhabi Lal, Lee, Sang Yeul, Jeong, Byeong-Seon, Kim, Jung-Ae, Nam, Tae-gyu
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6096353/
https://ncbi.nlm.nih.gov/pubmed/30151084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00156a
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