Combined Influence of B-Cell Receptor Rearrangement and Somatic Hypermutation on B-Cell Class-Switch Fate in Health and in Chronic Lymphocytic Leukemia

A diverse B-cell receptor (BCR) repertoire is required to bind a wide range of antigens. BCRs are generated through genetic recombination and can be diversified through somatic hypermutation (SHM) or class-switch recombination (CSR). Patterns of repertoire diversity can vary substantially between di...

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Udgivet i:Front Immunol
Main Authors: Petrova, Velislava N., Muir, Luke, McKay, Paul F., Vassiliou, George S., Smith, Kenneth G. C., Lyons, Paul A., Russell, Colin A., Anderson, Carl A., Kellam, Paul, Bashford-Rogers, Rachael J. M.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095981/
https://ncbi.nlm.nih.gov/pubmed/30147686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01784
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