MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma

Glycine N-methyltransferase (GNMT) is a tumor suppressor for HCC. It is down-regulated in HCC, but the mechanism is not fully understood. MicroRNA-224 (miR-224) acts as an onco-miR in HCC. This study is the first to investigate miR-224 targeting the coding region of GNMT transcript. The GNMT-MT plas...

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Published in:Sci Rep
Main Authors: Hung, Jung-Hsien, Li, Chung-Hsien, Yeh, Ching-Hua, Huang, Pin-Cheng, Fang, Cheng-Chieh, Chen, Yen-Fu, Lee, Kuo-Jui, Chou, Chih-Hung, Cheng, Hsin-Yun, Huang, Hsien-Da, Chen, Marcelo, Tsai, Ting-Fen, Lin, Anya Maan-Yuh, Yen, Chia-Hung, Tsou, Ann-Ping, Tyan, Yu-Chang, Chen, Yi-Ming Arthur
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095880/
https://ncbi.nlm.nih.gov/pubmed/30115977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30682-5
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