Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes

Plants containing aristolochic acids (AA) are nephrotoxins. Glycine N-methyltransferase (GNMT) acts to bind environmental toxins such as benzo(a)pyrene and aflatoxin B1, translocate into nucleus, and alter hepatic metabolism. This study aims to determine the role of GNMT in AA-induced nephropathy. W...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Chang, Ming-Min, Lin, Chang-Ni, Fang, Cheng-Chieh, Chen, Marcelo, Liang, Peir-In, Li, Wei-Ming, Yeh, Bi-Wen, Cheng, Hung-Chi, Huang, Bu-Miin, Wu, Wen-Jeng, Chen, Yi-Ming Arthur
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934382/
https://ncbi.nlm.nih.gov/pubmed/29725048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22298-6
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars