Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes

Plants containing aristolochic acids (AA) are nephrotoxins. Glycine N-methyltransferase (GNMT) acts to bind environmental toxins such as benzo(a)pyrene and aflatoxin B1, translocate into nucleus, and alter hepatic metabolism. This study aims to determine the role of GNMT in AA-induced nephropathy. W...

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Publicado no:Sci Rep
Main Authors: Chang, Ming-Min, Lin, Chang-Ni, Fang, Cheng-Chieh, Chen, Marcelo, Liang, Peir-In, Li, Wei-Ming, Yeh, Bi-Wen, Cheng, Hung-Chi, Huang, Bu-Miin, Wu, Wen-Jeng, Chen, Yi-Ming Arthur
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934382/
https://ncbi.nlm.nih.gov/pubmed/29725048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22298-6
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