MASTL overexpression promotes chromosome instability and metastasis in breast cancer

MASTL kinase is essential for correct progression through mitosis, with loss of MASTL causing chromosome segregation errors, mitotic collapse and failure of cytokinesis. However, in cancer MASTL is most commonly amplified and overexpressed. This correlates with increased chromosome instability in br...

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Vydáno v:Oncogene
Hlavní autoři: Rogers, Samuel, McCloy, Rachael A., Parker, Benjamin L., Gallego-Ortega, David, Law, Andrew M. K., Chin, Venessa T., Conway, James R. W., Fey, Dirk, Millar, Ewan K. A., O’Toole, Sandra, Deng, Niantao, Swarbrick, Alexander, Chastain, Paul D., Cesare, Anthony J., Timpson, Paul, Caldon, C. Elizabeth, Croucher, David R., James, David E., Watkins, D. Neil, Burgess, Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095835/
https://ncbi.nlm.nih.gov/pubmed/29743597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0295-z
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