PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells

Entry into mitosis is driven by the phosphorylation of thousands of substrates, under the master control of Cdk1. During entry into mitosis, Cdk1, in collaboration with MASTL kinase, represses the activity of the major mitotic protein phosphatases, PP1 and PP2A, thereby ensuring mitotic substrates r...

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Publicado en:J Cell Sci
Autores principales: Rogers, Samuel, Fey, Dirk, McCloy, Rachael A., Parker, Benjamin L., Mitchell, Nicholas J., Payne, Richard J., Daly, Roger J., James, David E., Caldon, C. Elizabeth, Watkins, D. Neil, Croucher, David R., Burgess, Andrew
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852720/
https://ncbi.nlm.nih.gov/pubmed/26872783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.179754
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