PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells

Entry into mitosis is driven by the phosphorylation of thousands of substrates, under the master control of Cdk1. During entry into mitosis, Cdk1, in collaboration with MASTL kinase, represses the activity of the major mitotic protein phosphatases, PP1 and PP2A, thereby ensuring mitotic substrates r...

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Vydáno v:J Cell Sci
Hlavní autoři: Rogers, Samuel, Fey, Dirk, McCloy, Rachael A., Parker, Benjamin L., Mitchell, Nicholas J., Payne, Richard J., Daly, Roger J., James, David E., Caldon, C. Elizabeth, Watkins, D. Neil, Croucher, David R., Burgess, Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852720/
https://ncbi.nlm.nih.gov/pubmed/26872783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.179754
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