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Coalescing beneficial host and deleterious antiparasitic actions as an antischistosomal strategy

Conventional approaches for antiparasitic drug discovery center upon discovering selective agents that adversely impact parasites with minimal host side effects. Here, we show that agents with a broad polypharmacology, often considered ‘dirtier’ drugs, can have unique efficacy if they combine delete...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Chan, John D, Day, Timothy A, Marchant, Jonathan S
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095690/
https://ncbi.nlm.nih.gov/pubmed/30059006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35755
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