Ergot Alkaloids (Re)generate New Leads as Antiparasitics

Praziquantel (PZQ) is a key therapy for treatment of parasitic flatworm infections of humans and livestock, but the mechanism of action of this drug is unresolved. Resolving PZQ-engaged targets and effectors is important for identifying new druggable pathways that may yield novel antiparasitic agent...

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Bibliographic Details
Published in:PLoS Negl Trop Dis
Main Authors: Chan, John D., Agbedanu, Prince N., Grab, Thomas, Zamanian, Mostafa, Dosa, Peter I., Day, Timothy A., Marchant, Jonathan S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569474/
https://ncbi.nlm.nih.gov/pubmed/26367744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004063
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