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Coalescing beneficial host and deleterious antiparasitic actions as an antischistosomal strategy

Conventional approaches for antiparasitic drug discovery center upon discovering selective agents that adversely impact parasites with minimal host side effects. Here, we show that agents with a broad polypharmacology, often considered ‘dirtier’ drugs, can have unique efficacy if they combine delete...

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Pubblicato in:eLife
Autori principali: Chan, John D, Day, Timothy A, Marchant, Jonathan S
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095690/
https://ncbi.nlm.nih.gov/pubmed/30059006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35755
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