Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate)

Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor used in first-line combination antiretroviral therapy (cART). It is usually administered with nucleoside reverse transcriptase inhibitors (NRTI), many of which are substrates of OCT uptake solute carriers (SLC22A) and MATE (SLC47A),...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ceckova, Martina, Reznicek, Josef, Deutsch, Birgit, Fromm, Martin F., Staud, Frantisek
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095608/
https://ncbi.nlm.nih.gov/pubmed/30114293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202706
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