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Oral methylnaltrexone does not negatively impact analgesia in patients with opioid-induced constipation and chronic noncancer pain

PURPOSE: An oral formulation of methylnaltrexone has been developed for treating opioid-induced constipation (OIC). This manuscript examines the impact of oral methylnaltrexone, a peripherally acting µ-opioid receptor antagonist, on opioid analgesia. METHODS: This Phase III, randomized, double-blind...

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Bibliografski detalji
Izdano u:J Pain Res
Glavni autori: Webster, Lynn R, Israel, Robert J
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095122/
https://ncbi.nlm.nih.gov/pubmed/30147355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S160488
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