Analysis of opioid-mediated analgesia in Phase III studies of methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain

BACKGROUND: Subcutaneous methylnaltrexone is efficacious and well tolerated for opioid-induced constipation (OIC) but may theoretically disrupt opioid-mediated analgesia. METHODS: Opioid use, pain intensity, and opioid withdrawal (Objective Opioid Withdrawal Scale [OOWS] and Subjective Opiate Withdr...

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Detalhes bibliográficos
Publicado no:J Pain Res
Main Authors: Webster, Lynn R, Brenner, Darren M, Barrett, Andrew C, Paterson, Craig, Bortey, Enoch, Forbes, William P
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634837/
https://ncbi.nlm.nih.gov/pubmed/26586963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S88203
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