Effects of flexibility of the α2 chain of type I collagen on collagenase cleavage

Cleavage of collagen by collagenases such as matrix metalloproteinase 1 (MMP-1) is a key step in development, tissue remodeling, and tumor proliferation. The abundant heterotrimeric type I collagen composed of two α1(I) chains and one α2(I) chain is efficiently cleaved by MMP-1 at a unique site in t...

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Bibliografiska uppgifter
I publikationen:J Struct Biol
Huvudupphovsmän: Mekkat, Arya, Poppleton, Erik, An, Bo, Visse, Robert, Nagase, Hideaki, Kaplan, David L., Brodsky, Barbara, Lin, Yu-Shan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089644/
https://ncbi.nlm.nih.gov/pubmed/29763735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2018.05.002
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