Molecular Mechanism of Type I Collagen Homotrimer Resistance to Mammalian Collagenases

Type I collagen cleavage is crucial for tissue remodeling, but its homotrimeric isoform is resistant to all collagenases. The homotrimers occur in fetal tissues, fibrosis, and cancer, where their collagenase resistance may play an important physiological role. To understand the mechanism of this res...

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Autors principals: Han, Sejin, Makareeva, Elena, Kuznetsova, Natalia V., DeRidder, Angela M., Sutter, Mary Beth, Losert, Wolfgang, Phillips, Charlotte L., Visse, Robert, Nagase, Hideaki, Leikin, Sergey
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903388/
https://ncbi.nlm.nih.gov/pubmed/20463013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102079
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