Molecular Mechanism of Type I Collagen Homotrimer Resistance to Mammalian Collagenases

Type I collagen cleavage is crucial for tissue remodeling, but its homotrimeric isoform is resistant to all collagenases. The homotrimers occur in fetal tissues, fibrosis, and cancer, where their collagenase resistance may play an important physiological role. To understand the mechanism of this res...

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Detalhes bibliográficos
Main Authors: Han, Sejin, Makareeva, Elena, Kuznetsova, Natalia V., DeRidder, Angela M., Sutter, Mary Beth, Losert, Wolfgang, Phillips, Charlotte L., Visse, Robert, Nagase, Hideaki, Leikin, Sergey
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903388/
https://ncbi.nlm.nih.gov/pubmed/20463013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102079
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