Molecular Mechanism of Type I Collagen Homotrimer Resistance to Mammalian Collagenases

Type I collagen cleavage is crucial for tissue remodeling, but its homotrimeric isoform is resistant to all collagenases. The homotrimers occur in fetal tissues, fibrosis, and cancer, where their collagenase resistance may play an important physiological role. To understand the mechanism of this res...

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Hlavní autoři: Han, Sejin, Makareeva, Elena, Kuznetsova, Natalia V., DeRidder, Angela M., Sutter, Mary Beth, Losert, Wolfgang, Phillips, Charlotte L., Visse, Robert, Nagase, Hideaki, Leikin, Sergey
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903388/
https://ncbi.nlm.nih.gov/pubmed/20463013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102079
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